Mechanisms and biomarkers of airway epithelial cell damage in asthma: A review

Bronchial asthma is a heterogeneous disease with complex pathological mechanisms representing different phenotypes, including severe asthma. The airway epithelium major site of changes in due, part, to activation inflammatory and immune response noxious agents. Current imaging procedures are unable accurately measure epithelial remodeling. Damage cells occurs linked specific phenotypes endotypes which provides an opportunity for the identification biomarkers reflecting epithelial, airway, Identification patients more disruption using may also provide personalised therapeutic opportunities and/or markers successful intervention. Here, we review evidence ongoing cell dysregulation pathogenesis asthma, sentinel role how understanding these molecular basis candidate prediction, prevention, diagnosis, treatment monitoring.